Synthetic Strategies in the Preparation of Osimertinib

Abstract

Osimertinib is an oral small molecule epidermal growth factor receptor tyrosine kinase inhibitor and is mainly used clinically for the treatment of lung cancer. Lung cancer, as the cancer with the highest incidence and mortality rate in China, has a huge market demand for therapeutic drugs. However, the traditional synthetic process route has a low yield and serious pollution. In recent years, the development of new synthetic routes has become a research hotspot. This article mainly focuses on the synthesis of Osimertinib, with an emphasis on three aspects. This study examines the different synthetic routes of Osimertinib, comparing their efficiency and applicability. It also explores the novel catalysts which can be used in the synthesis process. Moreover, the derivatives of Osimertinib are also explored. By evaluating each synthetic route, this work aims to offer a strategic roadmap for future research endeavors and provide new ideas for the research on the synthetic process of this drug.